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Exercise 7A: Sequence Alignment
STA 4953 (Spring 2001)
Due 3/22/2001



Do not use the computer in any way to do this exercise.

  1. Find the best global alignment between the DNA sequences:

    AGTAGTCAAG
    AGAAGTAAG

    Use the following scoring system:
      score of a match = 1
      score of a mismatch = -1
      gap penalty function w(k) = -1 - 2k.

  2. Find the best local alignment between amino acid sequences:

    MAGSPVSSYS
    AGPESPHSAY

    using the BLOSUM 62 score matrix (which can be found in the notes of the 3/6 lecture) and a gap penalty w(k) = -1 - 2k.